Personally, I would never buy a truck known to have great 4x4 capability, in a 2x4 version. I would never buy any vehicle that isn’t 4x4, but that’s just how I grew up and where my taste will always be. Cars and fast trucks are cool I guess, but not for me. Maybe you’ll never need the 4wd, but maybe you’ll regret not having it at an unexpected time.
As for standard and automatic, that is usually personal preference. It’s obviously a big commitment to opt for a manual, and it can eventually get tiresome (especially in traffic). But some people don’t care and are diehard manual. If they offered a manual for the longbed, I would’ve done it. Performance-wise, both transmissions seem to have their quirks and both seem to be improved on the 2020 and/or if you install OVTune.